Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir

Article
Drug substance
Generic APIs
Process development

This article shares our process for developing an improved API synthesis of raltegravir. Through this process, the team isolated a new process intermediate and develop conditions to solve the selectivity issue typical of this production process, with no need for the use of protecting groups, making this route more efficient and sustainable than what has been previously reported. By completing efficiency comparisons with the previous processes, we were able to confirm the result as well.

Read the complete article, “Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir,” to learn more about our approach and the results.

View the full article (via ACS Publications)